Abstract
The synthesis and biological activity of a new series of 2-aryloxymethylmorpholine histamine H(3) antagonists is described. The new compounds are high affinity histamine H(3) ligands that penetrate the CNS and occupy the histamine H(3) receptor in rat brain.
MeSH terms
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Animals
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Brain / metabolism
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Histamine H3 Antagonists / chemical synthesis
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Histamine H3 Antagonists / pharmacokinetics
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Histamine H3 Antagonists / pharmacology*
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Morpholines / chemical synthesis
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Morpholines / pharmacokinetics
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Morpholines / pharmacology*
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Rats
Substances
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Histamine H3 Antagonists
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Morpholines